A Phase II Trial of Afatinib(BIBW 2992) in Third-line Treatment for Patients With Stage IIIB/IV Adenocarcinoma of the Lung Harbouring Wild-type Epidermal Growth Factor Receptor[EGFR]

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

To explore the efficacy of BIBW 2992 defined by the objective response rate (Complete Response, Partial Response) as determined by Response Evaluation Criteria in Solid Tumours[RECIST] 1.1 in the patients with advanced (stage IIIB or IV) adenocarcinoma of the lung harbouring wild-type EGFR.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Boehringer Ingelheim
• Treatments: Afatinib

Criteria

Inclusion criteria:

1. Pathologically confirmed stage IIIB/IV adenocarcinoma in non-small cell lung cancer[NSCLC]

2. Progressive disease following a second-line cytotoxic chemotherapy including at least one platinum-containing regimen

3. A known wild-type EGFR status

4. Patients 18 years of age or older

Exclusion criteria:

1. More than two prior cytotoxic chemotherapy treatment regimens for relapsed or metastatic disease

2. Prior treatment with EGFR targeting small molecules or antibodies

3. Radiotherapy or surgery within 4 weeks prior to study entry

4. Active brain metastasis

5. Known pre-existing interstitial lung disease

6. History or presence of clinically relevant cardiovascular abnormalities

7. Cardiac left ventricular function with resting ejection fraction of less than 50%

8. Absolute neutrophil count[ANC] < 1,500/mm3

9. Platelet count <100,000/mm3

10. Creatinine clearance<60ml/min or serum creatinine >1.5 times upper limit of normal

11. Women of childbearing potential, or men who are able to father a child, unwilling to use a medically acceptable method of contraception during the trial

12. Pregnancy or breast-feeding